201995-75-7

Upstream product

• 201995-66-6 (R)-2,N-Dimethoxy-2-((2R,4R,5S,6R)-5-methoxy-2-phenyl-6-trityloxymethyl-[1,3]dioxan-4-yl)-N-methyl-acetamide 
• 201995-65-5 (R)-2-Hydroxy-2-((2R,4R,5S,6R)-5-hydroxy-2-phenyl-6-trityloxymethyl-[1,3]dioxan-4-yl)-N-methoxy-N-methyl-acetamide 
• 201995-67-7 (R)-Methoxy-((2R,4R,5S,6R)-5-methoxy-2-phenyl-6-trityloxymethyl-[1,3]dioxan-4-yl)-acetaldehyde 
• 201995-64-4 (2R,4R,4aS,7R,7aS)-7-Hydroxy-2-phenyl-4-trityloxymethyl-tetrahydro-furo[3,2-d][1,3]dioxin-6-one 
• 201995-63-3 3,5-O-benzylidene-D-gulonolactone 
• 201995-71-3 (4S,5S,6R)-5-Hydroxy-4,6-dimethoxy-2-methyl-7-oxo-heptanoic acid tert-butyl ester 
• 56904-86-0 tert-butyl 2-(triphenylphosphoranylidene)propionate 

Downstream Products

• 201995-77-9 (4S,5R,6S,8R)-4,6-Dimethoxy-2,8-dimethyl-5-trimethylsilanyloxy-nonanedioic acid benzyl ester tert-butyl ester 
• 201995-84-8 (5S,6R)-6-[(1S,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-3-methyl-butyl]-5-methoxy-3-methyl-tetrahydro-pyran-2-one 
• 201995-92-8 (4S,5R,6S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-4,6-dimethoxy-2,8-dimethyl-5-trimethylsilanyloxy-nonanoic acid methyl ester 

Relevant academic research and scientific papers

Synthetic studies on the immunosuppressive agent FK-506: Construction of the polycarbonyl region

The C10-C17 fragment of the natural product, FK-506, has been stereoselectively synthesized from L-gulose. Methods for elaboration to the C1-C17 fragment and installation of the C9 carbonyl group are described.