201995-87-1

Upstream product

• 201995-90-6 (S)-1-(2-{(2S,3S,5S,6R)-6-[(1S,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-3-methyl-butyl]-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl}-acetyl)-piperidine-2-carboxylic acid methyl ester 
• 201995-94-0 (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-6,8-dimethoxy-4,10-dimethyl-3-oxo-7-trimethylsilanyloxy-undecanoyl]-piperidine-2-carboxylic acid methyl ester 
• 201995-96-2 (S)-1-[(4S,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-6,8-dimethoxy-4,10-dimethyl-3-oxo-7-trimethylsilanyloxy-undecanoyl]-piperidine-2-carboxylic acid methyl ester 
• 186581-53-3 diazomethane 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 201995-97-3 (S)-1-[(4R,6S,7R,8S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-2-diazo-7-hydroxy-6,8-dimethoxy-4,10-dimethyl-3-oxo-undecanoyl]-piperidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthetic studies on the immunosuppressive agent FK-506: Construction of the polycarbonyl region

The C10-C17 fragment of the natural product, FK-506, has been stereoselectively synthesized from L-gulose. Methods for elaboration to the C1-C17 fragment and installation of the C9 carbonyl group are described.