202001-00-1Relevant articles and documents
Synthesis of dihalophenylacetic acids using aromatic nucleophilic substitution strategy
Kowalczyk, Bruce A.
, p. 1411 - 1414 (2007/10/03)
A simple synthetic strategy to dihalophenylacetic acids and specifically 3,5-difluorophenylacetic acid an important pharmaceutical intermediate was developed. The aromatic nucleophilic substitution of dihalofluorobenzenes using the anion of ethyl cyanoacetate yielded ethyl dihalophenylcyanoacetates. The basic decarboxylation of the ethyl dihalophenylcyanoacetates produced targeted dihalophenylacetic acids.