202003-86-9Relevant academic research and scientific papers
CuI-catalyzed Sonogashira reaction for the efficient synthesis of 1H-imidazo[2,1-a]isoquinoline derivatives
Gang, Ma-Yong,Liu, Jian-Quan,Wang, Xiang-Shan
, p. 4698 - 4705 (2017)
The Sonogashira reaction first, and then intra-molecular hydroamination of alkyne catalyzed by CuI/o-phen was proved to be an efficient method for the synthesis of imidazo[2,1-a]isoquinoline, phenanthro[9′,10′:4,5]imidazo[2,1-a]isoquinoline and acenaphtho[1′,2′:4,5]imidazo [2,1-a]isoquinoline derivatives in the presence of Cs2CO3.
Synthesis and analgesic activities of 2-substituted-1H-phenantro [9,10- d] imidazoles
Isikdag,Ucucu,Oezdemir,Meric,Oeztuerk,Aydin,Ergun
, p. 453 - 456 (2007/10/03)
Some 2-substituted-1H-phenantro [9, 10-d] imidazole compounds were synthesized and their analgesic activities were determined on the Swiss albino mice (25-35 g) of either sex. In the synthesis, phenantrenequinone molecule was reacted with different aldehyde derivatives in acetic acid presence of ammonium acetate and finally 16 compounds were gained. All spectral and elemental analyses of the originale compounds were completed and their structures were elucidated. Analgesic activity of the compounds were examined by using the Tail-Clip method. 2-Phenyl-1H-phenantro [9, 10-d] imidazole (comp.1) and 2(4-chlorophenyl)-1H-phenantro [9, 10-d] imidazole (comp. 6) were found to be more active than the others and their LD50 values were found to be greater than 100 mg/kg (i.p).
Synthesis, spectroscopic studies and structural characterisation of some new 2-(phosphonioaryl)imidazolide betaines
Allen, David W.,Hawkrigg, Jacqueline,Adams, Harry,Taylor, Brian F.,Hibbs, David E.,Hursthouse, Michael B.
, p. 335 - 340 (2007/10/03)
The synthesis is described of three series of 2-(phosphonioaryl)(benz)imidazolide betaines, viz (i) the 2-(2-or 3- or 4-tributylphosphoniophenyl)benzimidazolides, (ii) the 2-(2- and 4-triorganophosphoniophenyl)-1H-phenanthro[9,10-d]imidazolides, and (iii)
