202004-44-2Relevant academic research and scientific papers
Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles
El Mamouni, El Hachemia,Cattoen, Martin,Cordier, Marie,Cossy, Janine,Arseniyadis, Stellios,Ilitki, Hocine,El Ka?m, Laurent
supporting information, p. 14490 - 14493 (2016/12/23)
The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji-Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.
Facile and high-yielding preparation of α-acetoxyphosphonates from α-hydroxyphosphonates assisted by microwave irradiation
Firouzabadi, Habib,Iranpoor, Nasser,Sobhani, Sara,Amoozgar, Zohreh
, p. 1771 - 1774 (2007/10/03)
A convenient and eco-friendly procedure is described for the efficient preparation of a variety of α-acetyloxyphosphonates from their corresponding α-hydroxyphosphonates using acetic anhydride under microwave irradiation in the absence of solvent.
Asymmetric dihydroxylation of 1-acyloxy-2(E)-alkenylphosphonates with AD-mix reagents. Effects of 1-acyloxy functional groups on the asymmetric dihydroxylation
Yokomatsu, Tsutomu,Yamagishi, Takehiro,Sada, Tomoyuki,Suemune, Kenji,Shibuya, Shiroshi
, p. 781 - 790 (2007/10/03)
Asymmetric dihydroxylation (AD) of a racemic mixture of 1-acyloxy-2(E)- alkenylphosphonates with AD-mix-α or -β reagents was examined. The kinetic rate of dihydroxylation was highly dependent upon the configuration of the 1- acyloxy functional group as we
