2021-74-1Relevant academic research and scientific papers
Alkylation and decarboxylation of ethyl 2-fluoro-3-oxobutanoate as a route to functionalised α-fluoro-ketones
Hutchinson,Sandford, Graham,Vaughan, Julian F.S.
, p. 2867 - 2876 (2007/10/03)
Alkylation and decarboxylation of α-fluoro-β-ketoesters such as ethyl 2-fluoro-3-oxobutanoate offers a versatile route to a range of fluoro-ketoalkenes, demonstrating the synthetic utility of using α-fluoro-β-ketoesters as synthons for the preparation of synthetically more sophisticated selectively fluorinated systems.
Synthesis, Regioselective Deprotonation, and Stereoselective Alkylation of Fluoro Ketimines
Welch, John T.,Seper, Karl W.
, p. 2991 - 2999 (2007/10/02)
Fluoroacetone imines of cyclohexylamine, valinol O-methyl ether, and phenylalaninol O-methyl ether and 2-fluorocyclohexanone imines of cyclohexylamine and phenylalaninol O-methyl ether were prepared.The temperature-dependent, regioselective deprotonation of these imines was employed in highly regioselective alkylation reactions.The deprotonation of fluoroacetone cyclohexylimine on the carbon bearing fluorine yielded only a single stereoisomer as determined by low temperature 19F NMR.In contrast, deprotonation of fluoroacetone O-benzyloximes was not regiospecific under any of the conditions examined.
The Temperature-Dependent Regioselective Deprotonation of Fluoroacetone Cyclohexylimine
Welch, John T.,Seper, Karl W.
, p. 119 - 120 (2007/10/02)
The temperature-dependent regioselective deprotonation of fluoroacetone cyclohexylimine was developed as a procedure for the regioselective alkylation of fluoroacetone.
Synthetic Approach to Versatile Chiral Molecules Containing a Fluorine Atom
Kitazume, Tomoya,Nakayama, Yoshimichi
, p. 2795 - 2799 (2007/10/02)
Studies of the synthetic tools for the preparation of chiral monofluorinated compounds, involving microbial asymmetric reduction, are described.The preparation and utility of such chiral monoflourinated compounds are reported.
