202124-76-3

Upstream product

• 202124-69-4 1-(4-Benzylpiperidinecarbonyl)methyl-5-cyanoindole 
• 15861-24-2 1H-indole-5-carbonitrile 
• 202124-95-6 {1-[2-(4-benzyl-piperidin-1-yl)-2-oxo-ethyl]-5-cyano-1H-indol-3-yl}-oxo-acetic acid methyl ester 
• 202124-67-2 5-cyanoindole-1-acetic acid 

Downstream Products

• 202124-77-4 1-[2-(4-benzyl-piperidin-1-yl)-2-oxo-ethyl]-3-(2-hydroxy-ethyl)-1H-indole-5-carbonitrile 
• 202123-79-3 {1-[2-(4-benzyl-piperidin-1-yl)-2-oxo-ethyl]-5-carbamimidoyl-1H-indol-3-yl}-acetic acid methyl ester 

Relevant academic research and scientific papers

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors

Thrombin, a serine protease, plays a central role in the initiation of thrombotic events. We report design, synthesis, and antithrombotic efficacy of XU817 (7), a nonpeptide 5-(amidino) indole thrombin inhibitor. Utilizing the co-crystal structure of XU817 bound in the active site of thrombin we were able to synthesize analogs with enhanced thrombin affinity.