202124-89-8Relevant articles and documents
A substituted indole -3 - acetic acid synthesis method (by machine translation)
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Paragraph 0074, (2017/05/02)
The present invention provides a substituted indole - 3 - acetic acid synthesis method, comprises the following steps: (1) in order to replace the indole as the starting material, with the acylation reagent under the action of catalyst through the tutor - acylation to obtain the 1, 3 - diacetyl substituted indole; (2) intermediate 1, 3 - diacetyl substituted indole does not need refining, directly with the morpholine and sulfur by the Willgerodt - Kindler rearrangement reaction, the inorganic under the catalysis of alkali hydrolysis, acidified to obtain substituted indole - 3 - acetic acid. (by machine translation)
Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors
Han,Dominguez,Stouten,Park,Duffy,Galemmo Jr.,Rossi,Alexander,Smallwood,Wong,Wright,Luettgen,Knabb,Wexler
, p. 4398 - 4415 (2007/10/03)
Thrombotic diseases are a major cause of death and morbidity. Factor Xa (fXa) plays a vital role in the regulation of normal homeostasis and abnormal intravascular thrombus development in the blood coagulation cascade. A novel series of fXa inhibitors inc