202191-13-7Relevant academic research and scientific papers
Novel carboxamide derivates salt and use of the same
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Paragraph 0139-0140; 0180; 0181, (2018/02/10)
The present invention relates to a novel carboxamide derivative salt having mental disorder remedial effects, and uses thereof. The salt as a compound represented by chemical formula 1 or a pharmaceutically allowable salt thereof can treat or prevent mental disorders such as depression, anxiety disorders, panic disorders, obsessive-compulsive disorders, phobias, attention deficit hyperactivity disorder, etc., can increase a remission rate, has fewer side effects and can effectively inhibit reabsorption of serotonin, norepinephrine or dopamine.COPYRIGHT KIPO 2017
Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors
Paudel, Suresh,Cao, Yongkai,Guo, Shuohan,An, Byeongkwan,Kim, Kyeong-Man,Cheon, Seung Hoon
, p. 6418 - 6426 (2015/10/05)
A series of 4-benzylpiperidine carboxamides were designed and synthesized, and tested for their dual (serotonin and norepinephrine) reuptake inhibition. The synthesis of 4-benzylpiperidine carboxamides involved two main steps: amidation and substitution. Derivatives with 3 carbon linker displayed better activity than with 2 carbon linker. 4-Biphenyl- and 2-naphthyl-substituted derivatives 7e and 7j showed greater dual reuptake inhibition than standard drug venlafaxine HCl.
Pyridine-oxazoline and quinoline-oxazoline ligated cobalt complexes: Synthesis, characterization, and 1,3-butadiene polymerization behaviors
Guo, Jun,Liu, Heng,Bi, Jifu,Zhang, Chunyu,Zhang, Hexin,Bai, Chenxi,Hu, Yanming,Zhang, Xuequan
, p. 305 - 312 (2015/08/06)
A series of cobalt complexes supported by pyridine-oxazoline (Pyox) and quinoline-oxazoline (Quox) were synthesized. Determined by single crystal X-ray crystallography, complexes 6a and 7c adopted distorted octahedron and trigonal bipyramid geometries, re
Catalyst-controlled Wacker-type oxidation of protected allylic amines
Michel, Brian W.,McCombs, Jessica R.,Winkler, Andrea,Sigman, Matthew S.
supporting information; experimental part, p. 7312 - 7315 (2010/11/05)
On the contrary: Utilizing the [Pd-(quinox)]-TBHP catalyst system, protected allylic amines were oxidized with high selectivity for the methyl ketone product. This is contrary to the results obtained by the substrate-controlled Tsuji-Wacker oxidation, which highlights the catalyst-controlled system presented here (see scheme). A variety of N-pro-tecting groups undergo selective oxidation with high ketone selectivity. TBHP = tert-butylhydroperoxide.
