202199-19-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 181210-34-4 (2S,3S,12R)-2-benzyloxy-1-(4-methoxyphenyldiphenylmethoxy)-octadec-4-yne-3,12-diol 
• 181210-21-9 (2R,3S,12R)-2-benzyloxy-3,12-di(tert-butyldimethylsiloxy)-octadec-4-enal 
• 181210-36-6 (2R,3S,14R)-2-benzyloxy-3,14-di(tert-butyldimethylsiloxy)-octadec-4-ene-1-ol 
• 181210-24-2 (2S,3S,9'R)-3-benzyloxy-2-(9'-(methoxymethoxy)pentadec-1-ynyl)-2,2-dimethyl-1,3-dioxane 
• 181210-25-3 (2S,3S,12R)-2-benzyloxyoctadec-4-yne-1,3,12-triol 
• 181211-29-0 1-benzyloxy-(7R)-7-(methoxymethoxy)-3-tridecyne 
• 181495-46-5 (4R,5R)-5-benzyloxy-4-(2-trimethylsilylethynyl)-2,2-dimethyl-1,3-dioxane 
• 181210-33-3 ethyl (3R)-3-(methoxymethoxy)nonanethioate 
• 181211-25-6 S-ethyl (R)-3-hydroxynonanethioate 
• 181211-15-4 1-bromo-(7R)-7-methoxymethoxytridecane 
• 181211-30-3 (7R)-7-(methoxymethoxy)-1-tridecanol 
• 181211-28-9 1-bromo-(3R)-3-(methoxymethoxy)nonane 
• 181211-26-7 (3R)-3-(methoxymethoxy)-1-nonanol 

Relevant academic research and scientific papers

Catalytic asymmetric syntheses of antifungal sphingofungins and their biological activity as potent inhibitors of serine palmitoyltransferase (SPT)

Unambiguous synthetic routes to sphingofungins B and F and to their stereoisomers have been developed based on the tin(II)-catalyzed asymmetric aldol reaction (Chiral Lewis Acid-Controlled Synthesis (CLAC Synthesis)). Efficient enantioselective synthesis using a catalytic amount of a chiral source as well as the effectiveness of this strategy for the synthesis of the sphingofungin family have been successfully demonstrated. Using the stereoisomers of sphingofungin B synthesized, the relevance of its stereochemistry to its SPT inhibitory activity has been revealed.