202212-63-3

Upstream product

• 3718-88-5 3-iodobenzylamine hydrochloride 
• 202212-60-0 2,6-dichloro-9-[2,3-di-O-benzoyl-4-(3-isoxazolyl)-β-D-erythrofuranosyl]-9H-purine 
• 212956-43-9 C₂₃H₁₉NO₈ 
• 33985-40-9 Methyl 2,3-O-isopropylidene-5-aldehydo-β-D-ribofuranoside 
• 212956-28-0 3-((3aR,4R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-isoxazole 
• 212956-21-3 (3aR,4R,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carbaldehyde oxime 

Relevant academic research and scientific papers

The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles

The synthesis and purinergic receptor binding of novel adenosine A3 ligands is described. Many selective A3 receptor agonists e.g. N-(3- iodobenzyl)adenosine-5'-methyluronamide (IB-MECA) contain a 4'- ribosylalkylamide moiety. We found that this amide and other 4'-functional groups could be replaced with an isosteric isoxazole, and the target molecules retained potent binding to the recombinant human A3 receptor.