20226-10-2

Upstream product

• 4721-98-6 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 74-88-4 methyl iodide 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 20944-13-2 N-<2-(3,4-dimethoxyphenyl)ethyl>-3-(3,4-dimethoxyphenyl)propionamide 
• 51842-87-6 3-(3,4-dimethoxy-phenyl)-propionyl chloride 
• 20944-14-3 1-[2-(3,4-dimethoxyphenyl)-ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline 
• 111427-24-8 N-<3-(3,4-dimethoxyphenyl)propionyl>-2-thiazolidine-2-thione 
• 2107-70-2 3,4-methoxycinnamic acid 

Downstream Products

• 32487-03-9 6,7-dimethoxy-1-(3,4-dimethoxyphenylethyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Succinct Syntheses of Methopholine, (±)-Homolaudanosine, and (±)-Dysoxyline via Metal-free One-Pot Double Alkylation on 1-Methyl-3,4-dihydroisoquinolines

A mild one-pot and metal-free condition was discovered to implement two different alkyl groups chemoselectively on 1-methyl-3,4-dihydroisoquinoline (1-Me-DHIQ), one at the nitrogen another at the C1-methyl group. This chemistry is compatible with various DHIQs as well as alkyl halides. Application of this chemistry facilitated the concise syntheses of methopholine, (±)-homolaudanosine, and (±)-dysoxyline, requiring only two steps from 6,7-dimethoxy-1-Me-DHIQ.

Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels

Several methoxylated 1,2,3,4-tetrahydroisoquinoliniums derived from N-methyl-laudanosine and N-methyl-noscapine were synthesized and evaluated for their affinity for apamin-sensitive binding sites. The quaternary ammonium derivatives have a higher affinit

Ruthenium dioxide in fluoro acid medium. III. Aplication to the synthesis of aporphinic, homoaporphinic and dibenzazocinic alkaloids. Studies towards the preparation of azafluoranthenic skeleton

Intramolecular oxidative couplings of phenylalkyltetrahydroisoquinoline precursors in aporphinic and homoaporphinic alkaloids by using RuO2,2H2O in fluoro acidic media were performed. A comparative study of our reagent with TTFA has been made with different precursors. The procedure was also extended to the synthesis of one dibenzazocinic alkaloid. Then, we attempted to synthetize the azafluoranthenic ring, using phenolic and non phenolic isoquinoline precursors.