202273-49-2

Upstream product

• 917-54-4 methyllithium 
• 202273-41-4 (R)-3-Chloromethyl-4-phenyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 202273-33-4 (R)-4-Phenyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 875-74-1 (R)-phenylglycine 

Downstream Products

• 4541-65-5 D-α-Phenylsarcosin-hydrochlorid 

Relevant academic research and scientific papers

Synthesis of α-N-ethylamino acids and their derivatives

A new synthesis of α-N-ethylamino acids starting from α-amino acids using hexafluoroacetone as protecting and activating agent is described. The hexafluoroacetone-protected N-ethylamino acid derivatives obtained are activated lactons. Therefore, they can be directly transformed without the need of an additional activation step with various nucleophiles into the corresponding carboxylic acid derivatives.

An efficient synthesis of N-methylamino acids and some of their derivatives

N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.