20231-41-8Relevant academic research and scientific papers
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
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Paragraph 00202; 00203, (2019/03/05)
The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
NEW HYDROXYACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 45, (2017/01/09)
Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description. Medicaments.
TOLL-LIKE RECEPTOR 9 AGONISTS
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Page/Page column 38, (2009/02/10)
The present invention provides TLR9 agonists comprising, as an active ingredient, a compound represented by formula (I): (wherein a represents 0 or 1; n represents an integer of 0 to 2; m represents an integer of 0 to 5; X1 and X2 each independently represent a hydrogen atom or hydroxy; Y represents an oxygen atom or a sulfur atom; -Q1-represents -O- or the like; -Q2- represents -O- or the like; -Z- represents -O- or the like; R1, R3 and R4 each independently represent hydroxy or the like; R2 and R5 each independently represent a hydrogen atom, hydroxy or the like; and A represents 6-aminopurin-9-yl or the like) or a pharmaceutically acceptable salt thereof, and the like.
Total synthesis of (+)-A83543A [(+)-lepicidin A]
Evans, Darid A.,Cameron Black
, p. 4497 - 4513 (2007/10/02)
The first synthesis of the macrolide insecticide A83543A (lepicidin A) has been completed using a Diels-Alder strategy to construct the carbocyclic framework. Diene synthesis through Pd-catalyzed Stille coupling of a macrocyclic vinylstannane and suitably functionalized vinyl iodide was followed by a diastereoselective Lewis acid-mediated intramolecular Diels-Alder reaction to construct the trans hydrindene subunit. Refunctionalization and intramolecular aldol condensation afforded the differentially protected (+)-lepicidin A aglycon. Successive glycosidations with 2,3,4-tri-O-methyl-D-rhamnose and N-protected L-forosamine followed by deprotection and methylation completed the synthesis of the enantiomer of the natural product.
METHYLATION OF METHYL 6-O-TRITYL-α-D-MANNOPYRANOSIDE - A NEW ROUTE TO THE SYNTHESIS OF SOME METHYL ETHERS OF D-MANNOSE
Grishkovets, V. I.,Chirva, V. Ya.
, p. 404 - 407 (2007/10/02)
The partial methylation of methyl 6-O-trityl-α-D-mannopyranoside by Kuhn's method (BaO, Ba(OH)2*8H2O, CH3I) in dimethylformamide and dimethyl sulfoxide has been studied.Simple methods are proposed for obtaining the 3- and 4-mono-O-, the 2,3-, the 2,4- and 3,4-di-O-, and the 2,3,4-tri-O-methyl ethers of methyl 6-O-trityl-α-D-mannopyranoside.
