20239-99-0

Usage

Uses

Used in Photodynamic Therapy for Cancer Treatment:
Pheophorbide b is used as a photosensitizer for inducing apoptosis in cancer cells when activated by light. It has shown promising results in the treatment of various types of cancer, including solid tumors.
Used in Pharmaceutical Industry:
Pheophorbide b is used as a potential candidate for the development of pharmaceutical products due to its antioxidant and anti-inflammatory properties. These properties may contribute to the prevention and treatment of various diseases and conditions.
Used in Nutraceutical Industry:
Pheophorbide b is used as a potential ingredient in nutraceutical products for its health-promoting benefits. Its antioxidant and anti-inflammatory properties may support overall health and well-being.
However, it is important to note that further research is needed to fully understand the potential benefits and risks of using pheophorbide b in medical and industrial applications.

Upstream product

• 3147-18-0 pheophytin b 
• 3147-18-0 pheophytin b 

Downstream Products

• 30959-24-1 rhodin g₇ 
• 5522-72-5 3¹,3²-dihydro-pheophorbide-b-methyl ester 
• 56211-47-3 3¹,3²-dihydro-pheophorbide-b 
• 82040-65-1 3¹,3²-didehydro-7-demethyl-7-formylphytochlorin 
• 5522-71-4 methyl pheophorbide b 

Relevant academic research and scientific papers

Synthesis of Covalently Linked dimeric Derivatives of Chlorophyll a, Pyrochlorophyll a, Chlorophyll b, and Bacteriochlorophyll a

Bis(chlorophyllide) ethylene glycol diesters were prepared for each of the title compounds.Pheophytins a and b isolated from alfalfa and bacteriochlorophyll a isolated from R.sphaeroides were treated with 80percent aqueous trifluoroacetic acid to yield the corresponding pheorbides.Pyropheophorbide was prepared by a literature procedure.Carbonic anhydride and benzotriazole-1-methanesulfonate activation methods were used in the esterification of the pheophorbides with ethylene glycol at ambient temperature.Each method yielded 75percent+ of the pheophorbide ethylene glycol monoester.These monoesters were treated with equimolar amounts of the corresponding pheophorbide by using benzotriazole-1-methanesulfonate/4-(dimethylamino)pyridine in CH2Cl2 or dicyclohexylcarbodiimide/4-(dimethylamino)pyridine in CH2Cl2 at ambient temperature.Yields of bis-(pheophorbide) ethylene glycol diesters averaged about 50percent for the former method and 70percent for the latter method.Insertion of the magnesium atoms into the a series macrocycles was accomplished with iodomagnesium 2,6-di-tert-butyl-4-methylphenolate, IMgBHT, in CH2Cl2, while the metalation of the b and bacterial series macrocycles was carried out with a mixture of IMgBHT and lithium 2,2,6,6-tetramethylpiperidie in thiophene, all at ambient temperature.Both mono- and dimethalated derivatives were isolated and characterized in each case.