202409-73-2Relevant articles and documents
2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors
Dube, Daniel,Brideau, Christine,Deschenes, Denis,Fortin, Rejean,Friesen, Richard W.,Gordon, Robert,Girard, Yves,Riendeau, Denis,Savoie, Chantal,Chan, Chi-Chung
, p. 1715 - 1720 (1999)
A series of novel 2-alkoxy, 2-thioalkoxy and 2-amino-3-(4- methylsulfonyl)phenylpyridines has been synthesized and shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. Structure-activity relationship studies have demonstrated that central pyridine ring substituents play an important role in the COX-2 potency, selectivity vs the COX-1 enzyme, and oral activity.
2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2
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Page 27, (2010/02/07)
The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
Substituted pyridines as selective cyclooxygenase-2 inhibitors
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, (2008/06/13)
The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
