20242-40-4

Upstream product

• 75055-73-1 1-(4-pyridyl)-1,3-butanedione 
• 20495-73-2 1-pyridin-4-yl-butane-1,3-dione 3-oxime 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 127-06-0 acetone oxime 
• 872-85-5 pyridine-4-carbaldehyde 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 96604-89-6 3-dimethylamino-1-(4-pyridyl)-2-buten-1-one 
• 106808-13-3 3-hydroxylamino-4-phenylsulphonyl-1-(4-pyridyl)but-2-en-1-one 
• 106807-83-4 (Z)-4-Benzenesulfonyl-3-methylsulfanyl-1-pyridin-4-yl-but-2-en-1-one 
• 106808-14-4 3-phenylsulphonylmethyl-5-(4-pyridyl)isoxazole 

Downstream Products

• 20242-33-5 1-Propyl-4-(3-methyl-5-isoxazolyl)-pyridiniumbromid 
• 18704-51-3 1-(2-Methoxy-ethyl)-4-(3-methyl-5-isoxazolyl)-pyridiniumchlorid 
• 20242-36-8 1-Cyclopropylmethyl-4-(3-methyl-5-isoxazolyl)-pyridiniumbromid 
• 20242-34-6 1-Allyl-4-(3-methyl-5-isoxazolyl)-pyridiniumchlorid 
• 18704-53-5 4-(3-methyl-isoxazol-5-yl)-1-(3-phenyl-allyl)-pyridinium; chloride 
• 61334-89-2 1-(3-p-fluorobenzoylpropyl)-4-(3-methyl-5-isoxazolyl)pyridinium perchlorate 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of novel 5-(heteroaryl)isoxazole derivatives

The synthesis, characterization and antibacterial activity of novel isoxazole derivatives were reported. 3-Di (alkylamino)acryloalkanones were prepared and used as synthons to get the target isoxazole derivatives via reaction with hydroxylamine hydrochloride or hydroxylamine-O-sulphonic acid.

New isoxazole derivatives designed as nicotinic acetylcholine receptor ligand candidates

In this work we report the synthesis and evaluation of the analgesic properties of new isosteric heterocyclic derivatives, presenting the isoxazole nucleus, designed as nicotinic acetylcholine receptor ligand candidates, analogues to alkaloid epibatidine. Compound 2-(3-methyl-5-isoxazolyl)pyridine (3) presented the best analgesic profile of this series in hot plate test, which was partially prevented by pretreatment with nicotinic receptor antagonist mecamylamine.

A Regioselective Synthesis of 3,5-Disubstituted Isoxazoles

The 3-aryl-5-, and 5-aryl-3-(phenylsulphonylmethyl)isoxazoles (6) and(9) respectively were regioselectively prepared from 1-aryl-3-methylthio-4-phenylsulphonylbut-2-en-1-one (1).As an application of the present method, 3-methyl-5-(4-.pyridyl)isoxazole (2)

STUDIES ON ISOMERIC PYRIDYLISOXAZOLES

Data concerning the reaction between hydroxylamine hydrochloride and 1-(2-pyridyl)-3-phenyl- (I a) and 1-(2-thienyl)-3-phenyl-1,3-propanedione (I l) disagree with those previously reported in literature.The same reaction was also studied employing a series of 1,3-diketones-1-(pyridyl)-substituted I b-i.The direction of enolization of 1,3-diketones accounted for the isomeric isoxazoles formation.