202466-68-0

Basic information

• Product Name: RO 04-6790
• Synonyms: 4-amino-n-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide;4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide;BenzenesulfonaMide, 4-aMino-N-[2,6-bis(MethylaMino)-4-pyriMidinyl]-;4-amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide
• CAS NO: 202466-68-0
• Molecular Formula: C₁₂H₁₆N₆O₂S
• Molecular Weight: 381.2813
• Mol File: 202466-68-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 595.8°C at 760 mmHg
• Flash Point: 314.1°C
• Appearance: white/
• Density: 1.495
• Vapor Pressure: 3.69E-14mmHg at 25°C
• Storage Temp.: Store at -20°C
• Solubility: DMSO: >10mg/mL
• PKA: 9.16±0.50(Predicted)
• CAS DataBase Reference: RO 04-6790(CAS DataBase Reference)
• NIST Chemistry Reference: RO 04-6790(202466-68-0)
• EPA Substance Registry System: RO 04-6790(202466-68-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DA9462500
• Hazardous Substances Data: 202466-68-0(Hazardous Substances Data)

Usage

Uses

Ro 04-6790 is a SR-6 antagonist.

Biological Activity

Potent and selective 5-HT 6 receptor antagonist (pK i values are 7.26 and 7.35 at rat and human 5-HT 6 receptors respectively). Displays no affinity at a range of other receptors (IC 50 > 10 μ M). Induces stretching behavior in rats in vivo .

InChI:InChI=1/C12H16N6O2S.2ClH/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H

Upstream product

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• 20246-53-1 (2R,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexanoic acid 
• 202464-89-9 (S)-Rasagiline Mesylate 
• 202464-88-8 (S)-Rasagiline Mesylate 
• 202463-68-1 1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-4-MORPHOLINYL-1H-PYRAZOLE-3-CARBOXAMIDE 
• 20246-33-7 Gulonic 
• 202463-00-1 PG 97-269 
• 202462-87-1 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXAMIDINE 
• 20246-15-5 1,1'-(decane-1,10-diyl)bis[4-amino-2-methylquinolinium] diundec-10-enoate 
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• 202460-49-9 1,3-Propanediamine,N-(5-nitro-2-pyridinyl)-(9CI) 

Downstream Products

• 20246-69-9 cadmium bis(pentyldithiocarbamate) 
• 202467-69-4 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid 
• 202467-76-3 C4 Dihydroceramide 
• 20246-81-5 4,4'-Dinitrodiphenic acid 
• 202468-25-5 15N4, 99%) 
• 202468-27-7 l-aspartic acid-13c4,15n 
• 202468-69-7 1,2-EPOXYPROPANE-D6 
• 202468-80-2 BUTYRIC ACID (D8) 
• 2024-70-6 FURFURYL ETHYL SULFIDE 
• 202471-31-6 Benzenemethanamine, N-hydroxy-4-(1-methylethyl)- (9CI) 
• 202471-84-9 Glomeratose A 
• 202473-18-5 L-Proline, 4-amino-3-hydroxy-, (3S,4R)- (9CI) 
• 202473-21-0 L-Proline, 4-amino-3-hydroxy-, (3R,4S)- (9CI) 
• 202473-22-1 L-Proline, 3-amino-4-hydroxy-, (3R,4R)- (9CI) 

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