202466-68-0 Usage
Uses
Ro 04-6790 is a SR-6 antagonist.
Biological Activity
Potent and selective 5-HT 6 receptor antagonist (pK i values are 7.26 and 7.35 at rat and human 5-HT 6 receptors respectively). Displays no affinity at a range of other receptors (IC 50 > 10 μ M). Induces stretching behavior in rats in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 202466-68-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,4,6 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 202466-68:
(8*2)+(7*0)+(6*2)+(5*4)+(4*6)+(3*6)+(2*6)+(1*8)=110
110 % 10 = 0
So 202466-68-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N6O2S.2ClH/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9;;/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18);2*1H
202466-68-0Relevant articles and documents
5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
Boes, Michael,Sleight, Andrew J.,Godel, Thierry,Martin, James R.,Riemer, Claus,Stadler, Heinz
, p. 165 - 178 (2007/10/03)
RO-04-6790 (6a) has been identified in a random screen for 5-HT6 receptor antagonists. In a medicinal chemistry optimisation program a series of analogs comprising N-heteroaryl- and N-arylbenzenesulfonamides have been synthesised and investigated for their binding affinity. Compounds with a log D profile indicative of brain penetration have been subjected to in vivo testing for reversal of a scopolamine-induced retention deficit in a passive avoidance paradigm.
