2025-77-6Relevant academic research and scientific papers
Solid-phase synthesis of monocyclic β-lactam derivatives
Schunk,Enders
, p. 8034 - 8042 (2007/10/03)
Liquid-phase studies concerning the solid-phase synthesis of monocyclic β-lactams via the esterenolate imine condensation route have been conducted utilizing triazene esters 1 and 2 as model compounds. Esters were attached to benzylamine resin 6 by a triazene linker employing the respective diazonium salts. Immobilized ester-enolates 8 and 10 were reacted with various imines and imine precursors to give polymer-bound β-lactams 14 and 17 in different substitution patterns. Traceless cleavage from the triazene linker yields the desired β-lactams 16 and 19.
