202537-07-3Relevant academic research and scientific papers
2,3-Dihydro-1H-1,5-benzodiazepines: A conversion of thiolactams to amidines
Puodziunaite,Kosychova,Janciene,Stumbreviciute
, p. 1275 - 1281 (2007/10/03)
The synthesis of a new series of diversely N-4 substituted amidines of 2,3-dihydro-1H-1,5-benzodiazepine has been accomplished starting from tetrahydro-1,5-benzodiazepin-2-one derivatives. These compounds were transformed into the desired thiolactams 2a-i which reacted in the presence of mercuric chloride with ammonia, as well as primary or secondary amines to give amidines 3a-i. Hydrazidines 3j-l were prepared by treatment of thiolactams with an excess of hydrazine.
