202580-70-9Relevant academic research and scientific papers
4-(1,3-dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4- dichlorophenyl)pyrazolo[1,5-α]-1,3,5-triazine: A potent, orally bioavailable CRF1 receptor antagonist
He, Liqi,Gilligan, Paul J.,Zaczek, Robert,Fitzgerald, Lawrence W.,McElroy, John,Shen,Saye, Jo Anne,Kalin, Ned H.,Shelton, Steven,Christ, David,Trainor, George,Hartig, Paul
, p. 449 - 456 (2007/10/03)
Structure-activity studies in the pyrazolo[1,5-a]-1,3,5-triazine series led to the discovery that compound 11i (DMP696) is a potent hCRF1 receptor antagonist (K(i) = 1.7 nM vs 7.5 nM for α-hel-CRF(9-41), hCRF1 adenylate cyclase ICsu
