202595-63-9Relevant academic research and scientific papers
Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents
Raval, Preeti,Jain, Mukul,Goswami, Amitgiri,Basu, Sujay,Gite, Archana,Godha, Atul,Pingali, Harikishore,Raval, Saurin,Giri, Suresh,Suthar, Dinesh,Shah, Maanan,Patel, Pankaj
scheme or table, p. 3103 - 3109 (2011/06/24)
In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, novel thiophene substituted oxazole containing α-alkoxy-phenylpropanoic acid derivatives are designed as highly potent PPARα/γ dual agonists. These compounds were found to be efficacious at picomolar concentrations. Lead compound 18d has emerged as very potent PPARα/γ dual agonist demonstrating potent antidiabetic and lipid lowering activity at a very low dose and did not exhibit any significant signs of toxicity in rodents.
