2026-17-7Relevant academic research and scientific papers
Method for producing biaryl compound
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, (2008/06/13)
There is disclosed a method for producing a biaryl compound of formula (I): wherein R1 is the same or different and independently denotes a substituted or unsubstituted hydrocarbon group or the like, A and B denote an aromatic hydrocarbon ring having from 6 to 14 carbon atoms or the like, k and m independently denote an integer of from 0 to 5, and 1 denotes an integer of 1 or 2, which method is characterized by reacting an aromatic compound of formula (II): wherein R1, k and l denote the same as defined above, and X1 denotes a leaving group, with a Grignard reagent of formula (III): (R2). 9MgX2 (IIIg) wherein R2, B, and m denote the same as defined above and X2 denotes chlorine or the like, in the presence of a cyclic ether, or an acyclic ether having two or more ether oxygens in the molecule and a nickel catalyst.
