202644-99-3Relevant academic research and scientific papers
Synthesis, C-13 NMR and anticonvulsant activity of new isatin-based spiroazetidinones
Singh, G. S.,Singh, T.,Lakhan, R.
, p. 951 - 954 (2007/10/03)
A series of 1-aryl/cyclohexyl-3,3-diphenyl-1'-(diphenylacetyl)-2-oxospiro[azetidin-4,3'-indolin-2'-ones] 4a-h has been synthesized by the reaction of diphenylketene, generated in situ from the thermal decomposition of 2-diazo-1,2-diphenylethanone (1) with 3-N-aryl/cyclohexyliminoindolin-2-ones 2a-h in 2:1 molar ratio. These spiroazetidinones, also obtainable by an equimolar reaction of diphenylketene with 1-diphenylacetyl derivatives 3 of the latter, have been characterized on the basis of elemental and spectral (IR, 1H and 13C NMR and mass) analyses and screened for their anticonvulsant activity. Two compounds 4e and 4h exhibit highly significant activity against MES.
