202647-65-2

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 3370-81-8 3-O-methyl-D-glucopyranose 
• 53957-07-6 1,2,4,6-tetra-O-acetyl-3-O-methyl-D-glucopyranose 
• 108-98-5 thiophenol 
• 202647-64-1 Phenyl 6-O-benzyl-2,3-di-O-methyl-1-thio-α-D-glucopyranoside 
• 202647-51-6 2,6-Di-O-benzyl-4-O-levulinyl-3-O-methyl-α-D-glucopyranosyl-(1->4)-2-O-acetyl-6-O-benzyl-3-O-methyl-α-D-glucopyranose trichloroacetimidate 
• 4163-64-8 1,2,4,6-tetra-O-acetate-2-O-methyl-β-D-glucopyranoside 
• 202647-62-9 Phenyl 2,4,6-tri-O-acetyl-3-O-methyl-1-thio-α-D-glucopyranoside 
• 226064-74-0 Phenyl 4,6-O-benzylidene-2,3-di-O-methyl-1-thio-α-D-glucopyranoside 
• 332083-32-6 (4aR,6R,7R,8R,8aR)-8-Methoxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 

Relevant academic research and scientific papers

Experimental proof for the structure of a thrombin-inhibiting heparin molecule

Kinetic studies of thrombin inhibition by antithrombin in the presence of heparin have shown that thrombin binds to heparin in a preformed heparin-antithrombin complex. To study the relative position of the thrombin binding domain and the antithrombin bin

New synthetic heparin mimetics able to inhibit thrombin and factor Xa

Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT HI) binding pentasaccharide prolonged at the non- reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin.