202665-76-7Relevant academic research and scientific papers
THIOL SULFONE METALLOPROTEASE INHIBITORS
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, (2008/06/13)
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
THIOL SULFONE METALLOPROTEASE INHIBITORS
-
, (2008/06/13)
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols
Freskos, John N.,Mischke, Brent V.,DeCrescenzo, Gary A.,Heintz, Robert,Getman, Daniel P.,Howard, Susan C.,Kishore, Nandini N.,McDonald, Joseph J.,Munie, Grace E.,Rangwala, Shaukat,Swearingen, Craig A.,Voliva, Charles,Welsch, Dean J.
, p. 943 - 948 (2007/10/03)
We have discovered a new series of potent MMP inhibitors that are selective for MMP-13 over MMP-1 incorporating a γ-sulfone thiol.
