202722-76-7

Upstream product

• 213459-79-1 3-bromo-4-iodo-2,5-dimethoxyphenol 
• 207518-76-1 2,3-dihydrobenzo[1,4]dioxine-7-boronic acid 
• 207518-79-4 7-bromo-2-methoxy-2,3-dihydrobenzo[1,4]dioxine 
• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 207518-78-3 5-Bromo-2-(2,2-dimethoxy-ethoxy)-phenol 
• 202735-35-1 3-bromo-6-iodo-2,5-dimethoxyphenol 
• 202735-34-0 3-bromo-2,5-dimethoxyphenol 
• 1761-61-1 5-bromosalicyclaldehyde 
• 23145-26-8 5-bromo-2-[2,2-(dimethoxy)ethoxy]benzaldehyde 
• 68216-65-9 3-bromo-2,5-dimethoxybenzaldehyde 
• 207518-77-2 2,5-dimethoxy-4-(3-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)-biphenyl-3,4'-diol 

Relevant academic research and scientific papers

NOVEL USE OF TRICYCLIC COMPOUND

Pharmaceutical compositions for enhancing the expression of apoAI are provided, which are used as medicaments for treatment of cardiovascular diseases on the basis of improving the functions of HDL.Pharmaceutical compositions for enhancing the expression of apoAI which comprises a compound of formula (I): in which X1 and X2 are independently an aryl or heteroaryl that may be optionally substituted, a hydrogen, a halogen, or the like; ring A is a benzene ring or 6-membered aromatic heterocyclic ring containing 1 to 3 N atoms that may be optionally condensed with another aromatic ring; R1 to R4 are independently a hydrogen, a halogen, a lower alkyl, a lower alkoxy or the like; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them are disclosed.

Total synthesis of terprenin, a highly potent and novel immunoglobulin E antibody suppressant

Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both route make it possible to prepare 1 efficiently and in large quantity.

Total synthesis of terprenin, a novel immunosuppressive p-terphenyl derivative

We achieved a total synthesis of terprenin, a novel potent immunoglobulin E antibody suppressant which was obtained from the fermentation broth of Aspergillus candidus RF-5672 and has a highly oxygenated p-terphenyl skeleton with a prenyloxy side chain. The key steps relied on the Suzuki reaction to construct the terphenyl skeleton and on regioselective halogenations to selectively combine the aromatic rings. The highly efficient and practical production of this important natural product offers promise for the development of a new type of antiallergic drug.