202722-76-7Relevant articles and documents
NOVEL USE OF TRICYCLIC COMPOUND
-
Page/Page column 14; 16, (2008/06/13)
Pharmaceutical compositions for enhancing the expression of apoAI are provided, which are used as medicaments for treatment of cardiovascular diseases on the basis of improving the functions of HDL.Pharmaceutical compositions for enhancing the expression of apoAI which comprises a compound of formula (I): in which X1 and X2 are independently an aryl or heteroaryl that may be optionally substituted, a hydrogen, a halogen, or the like; ring A is a benzene ring or 6-membered aromatic heterocyclic ring containing 1 to 3 N atoms that may be optionally condensed with another aromatic ring; R1 to R4 are independently a hydrogen, a halogen, a lower alkyl, a lower alkoxy or the like; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them are disclosed.
Total synthesis of terprenin, a highly potent and novel immunoglobulin E antibody suppressant
Kawada, Kenji,Arimura, Akinori,Tsuri, Tatsuo,Fuji, Masahiro,Komurasaki, Tadafumi,Yonezawa, Shuji,Kugimiya, Akira,Haga, Nobuhiro,Mitsumori, Susumu,Inagaki, Masanao,Nakatani, Takuji,Tamura, Yoshinori,Takechi, Shozo,Taishi, Teruhiko,Kishino, Junji,Ohtani, Mitsuaki
, p. 973 - 975 (2007/10/03)
Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both route make it possible to prepare 1 efficiently and in large quantity.