202751-32-4

Basic information

• Product Name: 2-[[(4-METHOXYPHENYL)SULFONYL]AMINO]-4-METHYLPENTANOIC ACID
• Synonyms: 2-[[(4-METHOXYPHENYL)SULFONYL]AMINO]-4-METHYLPENTANOIC ACID;AKOS BC-3177
• CAS NO: 202751-32-4
• Molecular Formula: C13H19NO5S
• Molecular Weight: 301.36
• Mol File: 202751-32-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[[(4-METHOXYPHENYL)SULFONYL]AMINO]-4-METHYLPENTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[(4-METHOXYPHENYL)SULFONYL]AMINO]-4-METHYLPENTANOIC ACID(202751-32-4)
• EPA Substance Registry System: 2-[[(4-METHOXYPHENYL)SULFONYL]AMINO]-4-METHYLPENTANOIC ACID(202751-32-4)

Safety Data

• Hazardous Substances Data: 202751-32-4(Hazardous Substances Data)

Upstream product

• 61-90-5 L-leucine 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 328-38-1 (R)-leucine 

Relevant articles and documents

Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy

AIMP2-DX2, a splicing variant of AIMP2, is up-regulated in lung cancer, possesses oncogenic activity, and results in tumorigenesis. Specifically inhibiting the interaction between AIMP2-DX2 and HSP70 to suppress AIMP2-DX2-dependent cancers with small molecules is considered a promising avenue for cancer therapeutics. Optimization of hit BC-DXI-04 (IC50 = 40.1 μM) provided new potent sulfonamide based AIMP2-DX2 inhibitors. Among these, BC-DXI-843 showed improved inhibition against AIMP2-DX2 (IC50 = 0.92 μM) with more than 100-fold selectivity over AIMP2 in a luciferase assay. Several binding assays indicated that this compound effectively induces cancer cell apoptosis by specifically interrupting the interaction between DX2 and HSP70, which leads to the degradation of DX2 via Siah1-mediated ubiquitination. More importantly, BC-DXI-843 demonstrated in vivo efficacy in a tumor xenograft mouse model (H460 cells) at a dosage of 50 mg/kg, suggesting it as a promising lead for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.

Carbonic anhydrase and matrix metalloproteinase inhibitors: Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes

The 14 different carbonic anhydrase (CA, EC 4.2.1.1) isozymes as well as the 23 different matrix metalloproteinases (MMPs) isolated up to now in higher vertebrates play important physiological functions in these organisms. Unsubstituted sulfonamides act a