202751-95-9

Basic information

• Product Name: FMOC-D-ALANINOL
• Synonyms: N-ALPHA-FMOC-D-ALANINOL;N-(9-FLUORENYLMETHOXYCARBONYL)-D-ALANINOL;N-FMOC-D-ALANINOL;FMOC-D-ALA-OL;FMOC-D-ALANINOL;FMOC-(R)-2-AMINO-1-PROPANOL;N-alpha-(9-Fluorenylmethyloxycarbonyl)-D-alaninol, (R)-N-(9-Fluorenylmethyloxycarbonyl)-2-amino-1-propanol;(R)-(9H-Fluoren-9-yl)Methyl (1-hydroxypropan-2-yl)carbaMate
• CAS NO: 202751-95-9
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.35
• Mol File: 202751-95-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 148-151 °C
• Boiling Point: 503.9°C at 760 mmHg
• Flash Point: 258.5°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 5.66E-11mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• PKA: 11.48±0.46(Predicted)
• CAS DataBase Reference: FMOC-D-ALANINOL(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-ALANINOL(202751-95-9)
• EPA Substance Registry System: FMOC-D-ALANINOL(202751-95-9)

Safety Data

• Hazardous Substances Data: 202751-95-9(Hazardous Substances Data)

Usage

General Description

FMOC-D-ALANINOL, also known as 9H-Fluoren-9-ylmethyl N-tert-butoxycarbonyl-D-alaninate, is a chemical compound commonly used in organic synthesis. It is a derivative of D-alanine, a naturally occurring amino acid, and the FMOC group, a common protecting group for amines in organic chemistry. FMOC-D-ALANINOL is typically used as a reagent in the synthesis of peptides and other organic molecules, where the FMOC group can be easily removed to reveal the free amine group of the D-alanine residue. FMOC-D-ALANINOL is important in the field of chemical synthesis and is used in various research and industrial applications.

InChI:InChI=1/C18H19NO3/c1-12(10-20)19-18(21)22-11-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,12,17,20H,10-11H2,1H3,(H,19,21)/t12-/m1/s1

Upstream product

• 35661-38-2 N-(9-fluorenylmethoxycarbonyl)-D-alanine 

Downstream Products

• 127043-32-7 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-alaninal 
• 1189357-94-5 4-nitrophenyl 2-[(9H-fluoren-9-ylmethoxy)carbonyl]aminopropylcarbonate 

Relevant articles and documents

LEFT-HANDED GAMMA-PEPTIDE NUCLEIC ACIDS, METHODS OF SYNTHESIS AND USES THEREFOR

A method of making optically pure preparations of chiral γΡΝΑ (gamma peptide nucleic acid) monomers is provided. Nanostructures comprising chiral γΡΝΑ structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed γΡΝΑ, and vice- versa, are provided.

A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols

A facile, efficient and racemization-free method for the synthesis of N-protected β-amino alcohols and peptaibols using N-hydroxysuccinimide active esters is described. Using this method, dipeptide, tripeptide and pentapeptide alcohols were isolated in high yields. The conformations in crystals of β-amino alcohol, dipeptide and tripeptide alcohols were analysed, with a well-defined type III β-turn being observed in the tripeptide alcohol crystals. This method is found to be compatible with Fmoc-, Boc- and other side-chain protecting groups.