20277-02-5

Basic information

• Product Name: (4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE
• Synonyms: CHEMBRDG-BB 3015278;ART-CHEM-BB B015278;(4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE;AKOS B015278;2-(4-hydroxyphenyl)acetohydrazide(SALTDATA: FREE);Benzeneacetic acid, 4-hydroxy-, hydrazide;2-(4-hydroxyphenyl)ethanehydrazide
• CAS NO: 20277-02-5
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 20277-02-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 455.7 °C at 760 mmHg
• Flash Point: 229.4 °C
• Appearance: /
• Density: 1.275 g/cm³
• Vapor Pressure: 6.37E-09mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE(20277-02-5)
• EPA Substance Registry System: (4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE(20277-02-5)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53
• Safety Statements: 26-36/37/39-61-60
• HazardClass: IRRITANT
• Hazardous Substances Data: 20277-02-5(Hazardous Substances Data)

Usage

General Description

(4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE, also known as 4-hydroxyphenylacetic hydrazide or PAAH, is a chemical compound with the molecular formula C8H10N2O3. It is an organic hydrazide derivative of 4-hydroxyphenylacetic acid, and is commonly used as a reagent in the synthesis of pharmaceuticals and agrochemicals. PAAH is a white to off-white crystalline powder with a melting point of 132-138°C, and is typically stored in cool, dry conditions away from light and air. Its primary applications include its use as an intermediate in the synthesis of other compounds, or as a building block in the preparation of peptide and protein conjugates for research purposes. Additionally, PAAH is also used as a reagent in the analysis of carbonyl compounds and in the synthesis of fragrances and flavorings.

InChI:InChI=1/C8H10N2O2/c9-10-8(12)5-6-1-3-7(11)4-2-6/h1-4,11H,5,9H2,(H,10,12)

Upstream product

• 37859-23-7 2-(p-hydroxyphenyl)acetyl chloride 
• 156-38-7 4-hydroxyphenylacetate 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 

Downstream Products

• 828251-44-1 (4-hydroxy-phenyl)-acetic acid [(3Z)-4-bromo-5-methyl-2-oxo-1,2-dihydro-indol-3-ylidene]-hydrazide 
• 1109271-22-8 5-(4-hydroxyphenyl)methyl-2-mercapto-1,3,4-oxadiazole 
• 1147839-91-5 (4-hydroxy-phenyl)-acetic acid (3,5-dibromo-2,4-dihydroxybenzylidene)-hydrazide 
• 1456613-97-0 2-(4-hydroxybenzyl)-5-thioxo-5,6-dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one 
• 1456614-19-9 C₁₃H₁₅N₅O₃S 
• 1276691-27-0 C₁₆H₁₅N₃O 

Relevant articles and documents

Co and Cu complexes with 2-acetylpyridine-4-hydroxy phenylacetyl acylhydrazone: Synthesis, crystal structures, CT-DNA/BSA binding behaviors, antibacterial activities and molecular docking studies

Two mononuclear complexes [Co(HL)L]NO3 (1) and [Cu(HL)2](NO3)2 (2)were synthesized from the reaction of 2-acetylpyridine-4-hydroxy phenylacetyl acylhydrazone (HL) with copper/cobalt nitrate hydrate. The single-c

Inhibitory potential of new phenolic hydrazide-hydrazones with a decoy substrate fragment towards laccase from a phytopathogenic fungus: SAR and molecular docking studies

Laccase from pathogenic fungi participates in both the delignification and neutralization of phytoantibiotics. Furthermore, it interferes with the hormone signaling in plants and catalyzes melanization. Infections of these pathogens contribute to loss in

Synthesis, structural elucidation and bioevaluation of 4-amino-1,2,4-triazole-3-thione's Schiff base derivatives

In this study, a series of ten triazole Schiff base derivatives 6a-j were synthesized through microwave assisted imine formation by reacting substituted amino triazole 5 with different substituted aldehydes. All the synthesized compounds were evaluated fo