20277-02-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
(4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals for its ability to facilitate the creation of various compounds with potential therapeutic and agricultural applications.
Used in Research:
(4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE is used as a building block in the preparation of peptide and protein conjugates for research purposes, enabling the exploration of new biochemical interactions and potential applications in medicine and biology.
Used in Analytical Chemistry:
(4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE is used as a reagent in the analysis of carbonyl compounds, contributing to the identification and quantification of these compounds in various chemical and biological contexts.
Used in Fragrance and Flavoring Industry:
(4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE is used as a reagent in the synthesis of fragrances and flavorings, adding to the diversity of scents and tastes in consumer products.

InChI:InChI=1/C8H10N2O2/c9-10-8(12)5-6-1-3-7(11)4-2-6/h1-4,11H,5,9H2,(H,10,12)

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 37859-23-7 2-(p-hydroxyphenyl)acetyl chloride 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 

Downstream Products

• 828251-44-1 (4-hydroxy-phenyl)-acetic acid [(3Z)-4-bromo-5-methyl-2-oxo-1,2-dihydro-indol-3-ylidene]-hydrazide 
• 828251-86-1 (4-hydroxy-phenyl)-acetic acid [(3Z)-6,7-dichloro-4-hydroxy-5-methoxy-2-oxo-1,2-dihydro-indol-3-ylidene]-hydrazide 
• 828251-83-8 (4-hydroxy-phenyl)-acetic acid [(3Z)-4-chloro-5-methoxy-2-oxo-1,2-dihydro-indol-3-ylidene]-hydrazide 
• 1456613-97-0 2-(4-hydroxybenzyl)-5-thioxo-5,6-dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one 
• 1456614-19-9 C₁₃H₁₅N₅O₃S 
• 1276691-27-0 C₁₆H₁₅N₃O 

Relevant academic research and scientific papers

Co and Cu complexes with 2-acetylpyridine-4-hydroxy phenylacetyl acylhydrazone: Synthesis, crystal structures, CT-DNA/BSA binding behaviors, antibacterial activities and molecular docking studies

Two mononuclear complexes [Co(HL)L]NO3 (1) and [Cu(HL)2](NO3)2 (2)were synthesized from the reaction of 2-acetylpyridine-4-hydroxy phenylacetyl acylhydrazone (HL) with copper/cobalt nitrate hydrate. The single-c

Thermal properties and CT-DNA/BSA binding behavior of a binuclear Cu(II) complex with acylhydrazone containing naphthalene ring

A novel Cu(II) complex [Cu2L2(NO3)2] with 2-hydroxy-1-naphthaldehyde-(4’hydroxy)phenylacetyl hydrazone (C19H14N2O2·H2O, HL) was synthesized. The structure o

Inhibitory potential of new phenolic hydrazide-hydrazones with a decoy substrate fragment towards laccase from a phytopathogenic fungus: SAR and molecular docking studies

Laccase from pathogenic fungi participates in both the delignification and neutralization of phytoantibiotics. Furthermore, it interferes with the hormone signaling in plants and catalyzes melanization. Infections of these pathogens contribute to loss in

Synthesis and biological evaluation of some new furoxan derivatives as anti-inflammatory agents

A new series of furoxan derivatives (3a-k) have been synthesized and characterized by their IR, 1H NMR and mass spectral data. All the compounds have been screened for their anti-inflammatory activity. The compounds 3a, 3b, 3f, 3g, and 3i which show significant anti-inflammatory activity have been further studied for their ulcerogenic activities and nitric oxide releasing properties. Furoxan derivative 3-memyl-4-[{2-(2-phenylacetyl)hydrazono}memyl]-furoxan 3f showed greater anti-inflammatory activity comparable to standard drug ibuprofen. The compound also showed reduced, ulcerogenicity and high nitric oxide releasing properties.

Synthesis, structural elucidation and bioevaluation of 4-amino-1,2,4-triazole-3-thione's Schiff base derivatives

In this study, a series of ten triazole Schiff base derivatives 6a-j were synthesized through microwave assisted imine formation by reacting substituted amino triazole 5 with different substituted aldehydes. All the synthesized compounds were evaluated fo

2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors

Human coxsackievirus B3 (CVB3) 3C protease plays an essential role in the viral replication of CVB3, which is a non-enveloped and positive single-stranded RNA virus belonging to Picornaviridae family, causing acute viral myocarditis mainly in children. During optimization based on SAR studies of benserazide (3), which was reported as a novel anti-CVB3 3Cpro agent from a screening of compound libraries, the 2,3,4-trihydroxybenzyl moiety of 3 was identified as a key pharmacophore for inhibitory activity against CVB3 3Cpro. Further optimization was performed by the introduction of various aryl-alkyl substituted hydrazide moieties instead of the serine moiety of 3. Among the optimized compounds, 11Q, a 4-hydroxyphenylpentanehydrazide derivative, showed the most potent inhibitory activity (IC50 Combining double low line 0.07 μM). Enzyme kinetics studies indicated that 11Q exhibited a mixed inhibitory mechanism of action. The antiviral activity against CVB3 was confirmed using the further derived analogue (14b) with more cell permeable valeryl ester group at the 2,3,4-trihydroxy moiety.

Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes

First organocatalytic intramolecular aldolization of ortho-diacylbenzenes to construct highly functionalized 3-hydroxyindanones is described. In this transformation a high trans-selectivity is achieved by the use of metal salt of amino acid. This method allows an easy access to the strained spirocyclic 3-hydroxyindanones related to a number of natural product frameworks. Synthesis of a new class of indole skeleton substituted by 3-hydroxyindanones added an extra essence to this new protocol.

Combinatorial synthesis of 3,5-Dimethylene substituted 1,2,4-Triazoles

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. 2011 Bentham Science Publishers Ltd.

Synthesis of some newer analogues of 4-hydroxyphenyl acetic acid as potent anti-inflammatory agents

A series of 1,3,4-oxadiazole and 1,2,4-triazole derivatives of 4-hydroxyphenyl acetic acid have been synthesized and evaluated for their anti-inflammatory activity by carrageenan induced rat paw edema method. The compounds, which showed good anti-inflammatory activity, were screened for their ulcerogenic and lipid peroxidation activities.