20280-93-7

Usage

Uses

Used in Pharmaceutical Industry:
3-acetyl-7-methyl-2H-chromen-2-one is used as an intermediate in the synthesis of various pharmaceuticals for its aromatic properties and potential therapeutic effects. Its unique chemical structure allows for the development of new drugs with improved efficacy and safety profiles.
Used in Agrochemical Industry:
3-acetyl-7-methyl-2H-chromen-2-one is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its aromatic properties and potential biological activity. Its incorporation into these products can enhance their effectiveness in controlling pests and weeds.
Used in Antioxidant Applications:
3-acetyl-7-methyl-2H-chromen-2-one is used as an antioxidant in various applications, including food preservation and cosmetic formulations. Its potential antioxidant properties can help prevent oxidative damage and extend the shelf life of products, as well as protect the skin from environmental stressors.
Used in Antimicrobial Applications:
3-acetyl-7-methyl-2H-chromen-2-one is used as an antimicrobial agent in various industries, such as food processing and healthcare, due to its potential to inhibit the growth of harmful microorganisms. Its antimicrobial properties can help maintain product safety and quality, as well as prevent the spread of infections.
Used in Fluorescence Probe Applications:
3-acetyl-7-methyl-2H-chromen-2-one is used as a fluorescence probe in biological and environmental applications, such as cell imaging and environmental monitoring. Its fluorescence properties allow for the detection and analysis of various biological processes and environmental contaminants, providing valuable insights into their behavior and impact.

InChI:InChI=1/C12H10O3/c1-7-3-4-9-6-10(8(2)13)12(14)15-11(9)5-7/h3-6H,1-2H3

Upstream product

• 698-27-1 4-methylsalicylaldehyde 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Synthesis and antiproliferative activity of hybrid thiosemicarbazone derivatives bearing coumarin and d-galactose moieties with EGFR inhibitory activity and molecular docking study

A series of substituted N-(2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl)thiosemicarbazones 5a–5j of substituted 3-acetylcoumarins were synthesized with yields of 45–68%. All synthesized thiosemicarbazones were evaluated for cytotoxic activity against several cancer cell lines, such as human breast adenocarcinoma cells MCF7, human liver cancer cells HepG2, human cervical cancer cells HeLa, human melanoma cancer cells SK-Mel-2, and human lung cancer cells LU-1 by using the standard MTT assay. The IC50 values for these cancer cell lines were 1.28–11.81 μM (for MCF-7), 1.53–22.12 μM (for HepG2), 1.43–48.16 μM (for HeLa), 1.82–14.62 μM (for SK-Mel-2), and 1.74–14.62 μM (for LU-1). Most of the compounds were noncytotoxic against human WI-38 normal cell line (IC50 > 16.9 μM). The antiproliferative mechanisms were studied via EGFR inhibition and molecular docking. Docking studies revealed that there are strong interactions between a typical compound with the receptor of the EGFR tyrosine kinase domain with Erlotinib. [Figure not available: see fulltext.]

Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having D-glucose moiety

Thiosemicarbazones 5a-j were synthesized with yields of 45–68% by condensation of 3-acetylcoumarins 3a-j and tetra-O-acetyl-β-D-thiosemicarbazide 4. All obtained thiosemicarbazones were screened for anti-microorganic activities against bacteria (B. subtilis, S. aureus, S. epidermidis, E. coli, P. aeruginosa, K. pneumoniae, S. typhimurium) and fungi (A. niger, C. albicans, S. cerevisiae, and A. flavus). Some compounds had significant inhibitory activity with MICs of 0.78–3.125 μM in comparison with 5a, including 5e,h,i for S. aureus, and 5c,f,i for S. epidermidis (Gram-(+) bacteria), 5c,f,g for E.coli, 5f for K. pneumoniae, 5b,c,g for P. aeruginosa, and 5i for S. typhimurium (Gram-(?) bacteria), 5d,h,i for A. niger, 5i for A. flavus, 5b,d,e,h for C. albicans, and 5i for S. cerevisiae. Compounds exhibited excellent activity against tested microorganism with MIC = 0.78 μM, including 5h,i (against S. aureus), 5h (against C. albicans), and 5i (against S. cerevisiae).

Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents

Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole–coumarin chalcones and pyrazole–quinoline chalcones were synthesized using multiple-step reactions. All the synthesized compounds were well c