202806-40-4

Basic information

• Product Name: 7-fluoro-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine
• CAS NO: 202806-40-4
• Molecular Formula: C₁₁H₁₃FN₄O₄
• Molecular Weight: 284.2437
• Mol File: 202806-40-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 655.1°C at 760 mmHg
• Flash Point: 350°C
• Density: 1.99g/cm³
• Vapor Pressure: 4.7E-18mmHg at 25°C
• Refractive Index: 1.808
• CAS DataBase Reference: 7-fluoro-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-fluoro-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine(202806-40-4)
• EPA Substance Registry System: 7-fluoro-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine(202806-40-4)

Safety Data

• Hazardous Substances Data: 202806-40-4(Hazardous Substances Data)

Upstream product

• 1053639-91-0 N-{4-acetylamino-1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-7-fluoro-1H-imidazo[4,5-c]pyridin-6-yl}-2,2,2-trifluoro-acetamide 
• 247024-44-8 4-amino-7-fluoro-6-trifluoroacetamido-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 247024-45-9 4-acetamido-6-amino-7-fluoro-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 247024-46-0 4-acetamido-7-fluoro-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 247024-28-8 5-(E)-(2-carbomethoxyvinyl)-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazole-4-carboxamide 
• 247024-36-8 4,6-diamino-7-fluoro-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 
• 1053647-27-0 1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-(cyano-hydroxy-methyl)-1H-imidazole-4-carboxylic acid amide 
• 247024-33-5 5-cyanofluoromethyl-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazole-4-carboxamide 
• 247024-34-6 5-cyanofluoromethyl-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazole-4-carbonitrile 
• 247024-27-7 5-iodo-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazoe-4-carboxamide 
• 59354-02-8 5-iodo-1-β-D-ribofuranosyl-1H-imidazole-4-carboxylic acid amide 
• 114485-07-3 5-formyl-1-(2,3,5-tris-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazole-4-carboxamide 
• 118744-90-4 5-iodo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-imidazole-4-carboxamide 
• 405231-08-5 4-chloro-7-fluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine 

Relevant articles and documents

Direct SNAr amination of fluorinated imidazo[4,5-c]pyridine nucleosides: Efficient syntheses of 3-fluoro-3-deazaadenosine analogs

This paper describes the ready preparation of 3,6-difluoro-3-deazapurine (4,7-difluoroimidazo[4,5-c]pyridine). This novel base was glycosylated under mild conditions using three different ribose sugar analogs. 3,6-Difluoro-3- deazapurine ribonucleoside an

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogensubstituted analogues (51 and 52), and 2′,3′ -dihalogen- substituted analogues (57-60) of 3-deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against L1210, P388, CCRF-CEM and B16F10 cell lines in vitro, producing IC50 values of 3, 7, 9 and 7μM, respectively. Several 3-deazaadenosine analogues (38, 51, 57 and 59) showed moderate to weak activity against hepatitis B virus.