202823-18-5

Basic information

• Product Name: 2(5-Chloro-2-methoxyphenyl)-2,4-dihydro-5-[3-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one
• CAS NO: 202823-18-5
• Molecular Weight: 369.73
• Mol File: 202823-18-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(5-Chloro-2-methoxyphenyl)-2,4-dihydro-5-[3-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5-Chloro-2-methoxyphenyl)-2,4-dihydro-5-[3-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one(202823-18-5)
• EPA Substance Registry System: 2(5-Chloro-2-methoxyphenyl)-2,4-dihydro-5-[3-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one(202823-18-5)

Safety Data

• Hazardous Substances Data: 202823-18-5(Hazardous Substances Data)

Relevant articles and documents

The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for urge urinary incontinence

A series of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones was prepared and shown by electrophysiological analysis to activate a cloned maxi-K channel mSlo (or hSlo) expressed in Xenopus laevis oocytes. The effects of these structurally novel maxi-K channel openers on bladder contractile function were studied in vitro using isolated rat bladder strips pre-contracted with carbachol. Several 1,3-diaryl 1,2,4-(4H)-triazol-5-one derivatives were found to be potent smooth muscle relaxants but this activity did not completely correlate with maxi-K channel opening.