Tofacitinib N-oxide is a chemical compound derived from tofacitinib, a medication used for treating rheumatoid arthritis and ulcerative colitis. As an oxidized form of tofacitinib, it is believed to possess similar pharmacological properties, primarily through its action as an inhibitor of the janus kinase (JAK) family of enzymes, which are pivotal in inflammatory processes. This inhibition is instrumental in mitigating inflammation and alleviating symptoms associated with autoimmune diseases such as arthritis and colitis. Tofacitinib N-oxide remains under investigation to ascertain its full therapeutic potential and safety profile.
2028267-73-2
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Basic information
- Product Name: N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine oxide
- Synonyms: N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine oxide;Tofacitinib N-Oxide
- CAS NO:2028267-73-2
- Molecular Formula: C16H20N6O2
- Molecular Weight: 328.369
- EINECS: -0
- Product Categories: N/A
- Mol File: 2028267-73-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine oxide(CAS DataBase Reference)
- NIST Chemistry Reference: N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine oxide(2028267-73-2)
- EPA Substance Registry System: N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine oxide(2028267-73-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 2028267-73-2(Hazardous Substances Data)
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2028267-73-2 Usage
Uses
Used in Pharmaceutical Industry:Tofacitinib N-oxide is used as an anti-inflammatory agent for its potential to manage the symptoms of autoimmune diseases such as rheumatoid arthritis and ulcerative colitis. Its mechanism of action involves inhibiting the JAK family of enzymes, thereby reducing inflammation and providing relief to affected individuals.
Used in Research and Development:
In the scientific community, Tofacitinib N-oxide serves as a subject of investigation for its potential therapeutic applications beyond the currently known uses. Researchers are exploring its safety profile and additional benefits it may offer in treating other inflammatory conditions or diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 2028267-73-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,2,8,2,6 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.Calculate Digit Verification of CAS Registry Number 2028267-73:
(9*2)+(8*0)+(7*2)+(6*8)+(5*2)+(4*6)+(3*7)+(2*7)+(1*3)=152
152 % 10 = 2
So 2028267-73-2 is a valid CAS Registry Number.
2028267-73-2Upstream product
2028267-73-2Downstream Products
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N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine oxide
