202828-83-9

Basic information

• Product Name: Pyrimidine, 5-(1-pentynyl)- (9CI)
• Synonyms: Pyrimidine, 5-(1-pentynyl)- (9CI)
• CAS NO: 202828-83-9
• Molecular Formula: C9H10N2
• Molecular Weight: 146.1891
• Product Categories: PYRIMIDINE
• Mol File: 202828-83-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 5-(1-pentynyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-(1-pentynyl)- (9CI)(202828-83-9)
• EPA Substance Registry System: Pyrimidine, 5-(1-pentynyl)- (9CI)(202828-83-9)

Safety Data

• Hazardous Substances Data: 202828-83-9(Hazardous Substances Data)

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 627-19-0 1-Pentyne 

Relevant articles and documents

A Nickel-catalyzed carbozincation of aryl-substituted alkynes

The addition of dialkylzincs or diphenylzinc to substituted phenylacetylenes in the presence of catalytic amounts of Ni(acac)2 in THF:NMP mixtures produces syn-carbozincation products with good to excellent regio- and stereoselectivity. After quenching with an electrophile (iodine, acyl chloride, allyl bromide) tetrasubstituted olefines are obtained in good to satisfactory yields. An intramolecular version of the reaction is possible using a terminal triple bond bearing an iodine at a remote position. More substituted iodo-alkynes furnish only reductive elimination products. An application to a stereoselective synthesis of (Z)-tamoxifen (Z:E > 99:1) has been developed.