2028284-70-8

Basic information

• Product Name: Sulfo DBCO-Amine
• Synonyms: Sulfo DBCO-Amine
• CAS NO: 2028284-70-8
• Molecular Formula: C21H21N3O5S
• Molecular Weight: 427.47354
• Mol File: 2028284-70-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Sulfo DBCO-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfo DBCO-Amine(2028284-70-8)
• EPA Substance Registry System: Sulfo DBCO-Amine(2028284-70-8)

Safety Data

• Hazardous Substances Data: 2028284-70-8(Hazardous Substances Data)

Usage

Description

Sulfo DBCO-Amine is a water-soluble building block that contains a DBCO (dibenzocyclooctyne) moiety. This reagent is designed to derivatize carboxyl-containing molecules or activated esters, such as NHS esters, with the DBCO moiety through a stable amide bond. Its low molecular weight ensures that it adds minimal spacer to the modified molecules, while the hydrophilic sulfonated spacer arm significantly enhances the water solubility of the DBCO-derivatized molecules. DBCO is widely utilized in copper-free Click Chemistry reactions, which are a type of bioorthogonal chemistry that allows for the selective and efficient formation of covalent bonds between molecules in living systems without interference from biological components.

Uses

Used in Bioconjugation:
Sulfo DBCO-Amine is used as a bioconjugation agent for attaching various biomolecules, such as peptides, proteins, and oligonucleotides, to other molecules or surfaces. The stable amide bond formed between the DBCO moiety and the target molecule ensures the covalent attachment, while the water solubility of the reagent facilitates its use in aqueous environments.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Sulfo DBCO-Amine is employed as a component in drug delivery systems. Its ability to form stable amide bonds with drug molecules or carriers allows for the development of targeted drug delivery systems that can specifically deliver therapeutic agents to disease sites, improving the efficacy and reducing the side effects of treatments.
Used in Bioimaging:
Sulfo DBCO-Amine is utilized in bioimaging applications as a means to label biomolecules for visualization under various imaging techniques, such as fluorescence microscopy or magnetic resonance imaging (MRI). The stable amide bond between the DBCO moiety and the imaging agent ensures that the label remains attached to the target molecule, allowing for accurate and reliable imaging.
Used in Biosensors:
In the development of biosensors, Sulfo DBCO-Amine serves as a key component for the immobilization of biological recognition elements, such as enzymes, antibodies, or nucleic acids, onto sensor surfaces. The stable amide bond formed between the DBCO moiety and the recognition element ensures a strong and durable attachment, which is crucial for the performance and reliability of the biosensor.
Used in Tissue Engineering:
In the field of tissue engineering, Sulfo DBCO-Amine is employed for the functionalization of scaffolds and other biomaterials. By forming stable amide bonds with the DBCO moiety, various bioactive molecules, such as growth factors or extracellular matrix components, can be immobilized onto the scaffolds. This immobilization enhances the bioactivity and biocompatibility of the materials, promoting cell adhesion, proliferation, and differentiation, ultimately contributing to the regeneration of tissues and organs.