202856-14-2

Upstream product

• 125080-07-1 Diethyl 2,6-diisopropyl-4-phenyl-pyridine-3,5dicarboxylate 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 78168-82-8 ethyl 3-amino-4-methyl-pent-2-enoate 

Downstream Products

• 202853-34-7 [2,6-Diisopropyl-5-((E)-pent-1-enyl)-4-phenyl-pyridin-3-yl]-methanol 

Relevant academic research and scientific papers

Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists

5-Hydroxyalkyl-4-phenylpyridines have been identified as a novel class of glucagon antagonists with potential utility for the treatment of diabetes. A lead structure with moderate activity was discovered through a high throughput screening assay. Structure-activity relationships led to the discovery of a potent antagonist, IC50=0.11 μM, more than 60-fold improvement over the lead structure.