202859-73-2

Basic information

• Product Name: 1-Cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one
• Synonyms: 2H-BENZIMIDAZOL-2-ONE, 1-CYCLOPROPYL-1,3-DIHYDRO-;1-CYCLOPROPYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE;2H-Benzimidazol-2-one,1-cyclopropyl-1,3-dihydro-(9CI);1-Cyclopropyl-1,3-dihydro-2H-Benzimidazol-2;1-Cyclopropyl-1H-benzo[d]imidazol-2(3H)-one;1-cyclopropyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
• CAS NO: 202859-73-2
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Product Categories: BENZIMIDAZOLE
• Mol File: 202859-73-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.35 g/cm³
• Refractive Index: 1.669
• CAS DataBase Reference: 1-Cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one(202859-73-2)
• EPA Substance Registry System: 1-Cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one(202859-73-2)

Safety Data

• Hazardous Substances Data: 202859-73-2(Hazardous Substances Data)

Usage

General Description

1-Cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one is a chemical compound that belongs to the class of benzimidazolones. It is a cyclic compound with a cyclopropyl group attached to the benzimidazole ring. 1-Cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one has potential pharmacological activities, and is being studied for its potential therapeutic applications. It may have potential use in the treatment of various diseases and conditions, and its chemical structure makes it a valuable target for medicinal chemistry research. Further studies are warranted to fully understand the properties and potential applications of 1-Cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one.

InChI:InChI=1/C10H10N2O/c13-10-11-8-3-1-2-4-9(8)12(10)7-5-6-7/h1-4,7H,5-6H2,(H,11,13)

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
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• 55432-23-0 cyclopropyl-(2-nitro-phenyl)-amine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 118482-03-4 N¹-cyclopropylbenzene-1,2-diamine 
• 57-13-6 urea 

Downstream Products

• 1352950-41-4 2-((8-(3-(3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid 
• 1352950-42-5 tert-butyl 2-((8-(3-(3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate 
• 1352950-32-3 tert-butyl 3-((8-(3-(3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate 
• 1352950-30-1 tert-butyl 2-((8-(3-(3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate 
• 1352949-77-9 tert-butyl 3-((8-(3-(3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate 
• 929565-03-7 1-cyclopropyl-3-[(1R)-3-(chloro)-1-phenylpropyl]-1,3-dihydro-2H-benzimidazol-2-one 
• 929565-00-4 1-cyclopropyl-3-[(1S)-3-(chloro)-1-phenylpropyl]-1,3-dihydro-2H-benzimidazol-2-one 

Relevant articles and documents

PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF

The present invention disclosed a class of pyrimidine or pyridine compounds, pharmaceutically acceptable salts, stereoisomers, prodrugs and solvates thereof, preparation method therefor and pharmaceutical compositions and pharmaceutical uses thereof. The compounds can inhibit the variants of EGFR (Epidermis Growth Factor Receptor) proteinases, and therefore can inhibit the growth of a variety of tumor cells effectively. The compounds can be used to prepare antitumor drugs, used for the treatment, combined therapy or prevention of various different cancers. The compounds can overcome the drug resistance induced by the existing first-generation EGFR inhibitors such as gefitinib, erlotinib and so on. Particularly, the compounds can be used to prepare drugs for treating or preventing diseases, disturbances, disorders or conditions mediated by epidermis growth factor receptor variants (such as L858R activated mutants, Exon19 deletion activated mutants and T790M resistant mutants).

RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I): wherein R1, R2 and R3 are defined herein, are useful as inhibitors of RSV.

Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors

A series of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors was discovered. Several compounds such as 15 and 20 showed good hNET potency. Compounds 15 and 20 also displayed excellent selectivity at hNET that appeared superior to those of reboxetine and atomoxetine (4 and 5).