20286-59-3

Upstream product

• 77-79-2 3-Sulfolene 
• 1485-00-3 5-((E)-2-nitroethenyl)-1,3-benzodioxole 
• 120-57-0 piperonal 

Downstream Products

• 73820-53-8 Acetic acid (2R,3R,3aS,12bS,12cS)-5-oxo-3-phenylselanyl-1,2,3a,4,5,7,12b,12c-octahydro-3H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-2-yl ester 
• 73820-53-8 (+/-)-2α-acetoxy-3β-benzeneselenenyl-α-lycoran-5-one 
• 93397-14-9 (4aR,11bS)-5-Benzyl-1,4,4a,5,6,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-3-one 
• 73820-52-7 Acetic acid (2R,3R,3aS,12bS,12cS)-5-oxo-2-phenylselanyl-1,2,3a,4,5,7,12b,12c-octahydro-3H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-3-yl ester 
• 93397-07-0 Benzoic acid (3R,4S)-4-benzo[1,3]dioxol-5-yl-3-benzoylamino-cyclohexyl ester 
• 93397-11-6 ((7S,8R)-8-Benzo[1,3]dioxol-5-yl-1,4-dioxa-spiro[4.5]dec-7-yl)-benzyl-methyl-amine 
• 93397-06-9 3-benzamido-4-(3,4-methylenedioxyphenyl)cyclohexanol 
• 93397-10-5 3-benzylamino-4-(3,4-methylenedioxyphenyl)cyclohexanone ethylene ketal 
• 93397-08-1 3-benzamido-4-(3,4-methylenedioxyphenyl)cyclohexanone 
• 93397-05-8 3-amino-4-(3,4-methylenedioxyphenyl)cyclohexanol 
• 63814-03-9 1,2,3,3a,4,5,12b,12c-octahydro-7H-1,3-benzodioxolo[5,6-c]pyrrolo[3,2,1-ij]quinoline 
• 110883-24-4 4-(2-carbomethoxyethyl)-5-(3,4-methylenedioxyphenyl)-4-nitrocyclohexene 

Relevant academic research and scientific papers

Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.

SYNTHESIS OF CEPHALOTAXINE ANALOGS

The efficient preparation of a pentacyclic analog 4 of the cephalotaxine skeleton is described.