202861-97-0Relevant articles and documents
A convenient conversion of α-aminoacids into NH-Boc protected α-aminoketones via imidazolides
Bonini, Bianca F.,Comes-Franchini, Mauro,Fochi, Mariafrancesca,Mazzanti, Germana,Ricci, Alfredo,Varchi, Greta
, p. 1013 - 1015 (1998)
Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylm
Synthesis of optically active N-protected α-aminoketones and α-amino alcohols
Zhou, Zheng Hong,Tang, Yi Long,Li, Kang Ying,Liu, Bing,Tang, Chu Chi
, p. 603 - 606 (2007/10/03)
A series of optically active N-protected α-aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the N-tert-butoxycarbonyl amino acids. Reduction of the α-aminoketones by sodium borohydride resulted in the corresponding 1,2-amino alcohols.
Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors
Sheppard, George S.,Florjancic, Alan S.,Giesler, Jamie R.,Xu, Lianhong,Guo, Yan,Davidsen, Steven K.,Marcotte, Patrick A.,Elmore, Ildiko,Albert, Daniel H.,Magoc, Terrance J.,Bouska, Jennifer J.,Goodfellow, Carole L.,Morgan, Douglas W.,Summers, James B.
, p. 3251 - 3256 (2007/10/03)
A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C- terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several comp
