202867-06-9

Upstream product

• 202867-04-7 N-benzoyl-N-(2-ethoxycarbonylethyl)-O-methyl-L-tyrosine ethyl ester 
• 202867-03-6 N-(2-ethoxycarbonylethyl)-O-methyl-L-tyrosine ethyl ester 
• 202867-02-5 N-(2-cyanoethyl)-O-methyl-L-tyrosine 
• 6230-11-1 O-Methyltyrosine 

Downstream Products

• 202867-08-1 1-benzoyl-2-(4-methoxybenzyl)pyrrolidin-3-one 
• 202866-74-8 1-Benzoyl-2-(4-methoxy-benzyl)-4-morpholin-4-ylmethyl-pyrrolidin-3-one 
• 202866-73-7 1-Benzoyl-2-(4-methoxy-benzyl)-4-piperidin-1-ylmethyl-pyrrolidin-3-one 
• 202866-87-3 [3-Hydroxy-2-(4-methoxy-benzyl)-4-morpholin-4-ylmethyl-pyrrolidin-1-yl]-phenyl-methanone 
• 202866-86-2 [3-Hydroxy-2-(4-methoxy-benzyl)-4-piperidin-1-ylmethyl-pyrrolidin-1-yl]-phenyl-methanone 
• 202866-72-6 1-Benzoyl-4-diethylaminomethyl-2-(4-methoxy-benzyl)-pyrrolidin-3-one 
• 202866-85-1 [4-Diethylaminomethyl-3-hydroxy-2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-phenyl-methanone 
• 202866-71-5 1-Benzoyl-4-dimethylaminomethyl-2-(4-methoxy-benzyl)-pyrrolidin-3-one 
• 202866-84-0 [4-Dimethylaminomethyl-3-hydroxy-2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-phenyl-methanone 

Relevant academic research and scientific papers

Synthesis of certain alkyl and aralkyl-4-[(alkylamino)methyl]-2-(4- methoxybenzyl)pyrrolidin-3-ols of anticonvulsant and neuroleptic profile

The synthesis of a 1-alkyl and aralkyl-4-[(alkylamino)methyl]-2-(4- methoxybenzyl)pyrrolidin-3-ols (1a-m) is described. The pharmacological evaluation of these compounds as anticonvulsants and as neuroleptics was performed. Compounds 1c,d,k and m (30 mg/kg) exhibited 100% protection in mice compared with diphenylhydantoin sodium (DPHS) (50 mg/kg) as a reference drug using maximum pentylenetetrazole seizures test. Compounds 1a,e,f,j and m displayed neuroleptic activity by measuring the latency, ambulation, grooming and rearing parameters using the open field test compared with chlorpromazine as reference drug.