20287-57-4Relevant academic research and scientific papers
Selective [15Nη2] labelling of an NG-propionylated arginine derivative
Kleinmaier, Roland,Gschwind, Ruth M.
, p. 29 - 32 (2009)
A straightforward convergent synthesis of [15N η2]-Bz-Arg(Nη-propionyl)-OEt*TFA is presented. In this approach, the guanidinylation reagent [15N 2]-N(boc)-N′(propionyl)-S-methylisothiourea is reacted with the side chain amino group of the title compound's ornithine precursor. The guanidinylation step is promoted by stoichiometric addition of HgCl2 to force completion. This method leads directly to the NG-acylated product and the acyl residue is principally modifiable in the last synthetic step of the guanidinylation reagent. Copyright
