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4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE is a heterocyclic chemical compound with the molecular formula C5H4N6. It features a pyrazole ring fused to a pyrimidine ring, classifying it among pyrazolopyrimidine derivatives. 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE is recognized for its potent inhibitory effect on Janus kinase 2 (JAK2), a key enzyme in cell growth and differentiation regulation. The unique structure and properties of 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE render it a promising candidate for pharmaceutical development, particularly for targeted therapies addressing diseases with dysregulated JAK2 signaling pathways.

20289-44-5

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20289-44-5 Usage

Uses

Used in Pharmaceutical Industry:
4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE is used as a therapeutic agent for the treatment of various diseases, primarily due to its ability to inhibit the JAK2 enzyme. Its application is particularly relevant in conditions where JAK2 dysregulation contributes to the disease pathology.
Used in Cancer Treatment:
In oncology, 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE is utilized as an anticancer agent targeting the JAK2 signaling pathway, which is implicated in the growth and proliferation of cancer cells. Its use may lead to the suppression of tumor growth and potentially the regression of various types of cancer.
Used in Inflammatory Disorder Management:
Beyond cancer treatment, 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE is also considered for use in managing inflammatory disorders. Since JAK2 plays a role in immune response signaling, its inhibition by 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE may help control inflammation associated with various conditions.
Used in Targeted Therapy Development:
4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE is employed as a lead compound in the development of targeted therapies. Its specificity for the JAK2 enzyme allows for the creation of drugs that can precisely address conditions involving this particular pathway, potentially reducing off-target effects and improving treatment efficacy.

Check Digit Verification of cas no

The CAS Registry Mumber 20289-44-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,8 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 20289-44:
(7*2)+(6*0)+(5*2)+(4*8)+(3*9)+(2*4)+(1*4)=95
95 % 10 = 5
So 20289-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)

20289-44-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Deaza-8-aza-adenine

1.2 Other means of identification

Product number -
Other names Aminopyrazolodpyrimidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20289-44-5 SDS

20289-44-5Upstream product

20289-44-5Downstream Products

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