202919-01-5

Upstream product

• 35500-75-5 (1R)-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one 
• 202918-99-8 ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid 
• 202919-23-1 ((1R,5R)-7-Oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-acetic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 202919-03-7 [(2R,3R)-2-Benzylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-acetic acid 2,2,2-trichloro-ethyl ester 
• 202919-07-1 [(3R,4R)-2-Oxo-3-(2-phenoxy-acetylamino)-4-phenylmethanesulfonyl-azetidin-1-yl]-acetic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of monocyclic &β-lactams related to cephalosporin and penicillin sulfones

Starting from the natural Penicillins G and V, a series of monocyclic β-lactams B were prepared, functionalized at N(1) by an acetyl residue and at C(3) and C(4), respectively, by an acylamino side-chain and a sulfone substituent in a cis-stereochemical relationship.The TAL and PIV prodrugs exhibited weak antibacterial activity in vitro.