202919-08-2Relevant academic research and scientific papers
Synthesis and antibacterial activity of monocyclic &β-lactams related to cephalosporin and penicillin sulfones
Marchand-Brynaert, Jacqueline
, p. 585 - 604 (2007/10/03)
Starting from the natural Penicillins G and V, a series of monocyclic β-lactams B were prepared, functionalized at N(1) by an acetyl residue and at C(3) and C(4), respectively, by an acylamino side-chain and a sulfone substituent in a cis-stereochemical relationship.The TAL and PIV prodrugs exhibited weak antibacterial activity in vitro.
