202925-23-3Relevant academic research and scientific papers
6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and pharmaceutical compositions
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, (2008/06/13)
The present invention discloses a novel 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid derivatives (formula I), with a process for their preparation, and with pharmaceutical compositions containing them as
Synthesis and antibacterial evaluation of certain quinolone derivatives
Chen,Fang,Sheu,Hsu,Tzeng
, p. 2374 - 2377 (2007/10/03)
A number of 7-substituted quinolone derivatives were synthesized and evaluated for antibacterial and cytotoxic activities. Preliminary results indicated that most compounds tested in this study demonstrated better activity against methicillin-resistant St
Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives
Fang,Chen,Sheu,Wang,Tzeng
, p. 3809 - 3812 (2007/10/03)
We report herein the synthesis and biological evaluation of two series of 7-substituted norfloxacin derivatives. Most compounds tested in this study demonstrated better activity against methicillin-resistant Staphylococcus aureus than norfloxacin. Prelimi
Synthesis and in-vitro antibacterial activities of N-substituted piperazinyl quinolones
Foroumadi,Emami,Davood,Moshafi,Sharifian,Tabatabaie,Farimani,Sepehri,Shafiee
, p. 559 - 563 (2007/10/03)
A series of N-substituted piperazinyl quinolones were prepared and evaluated for in-vitro antibacterial activity. Compounds having phenacyl group attached to the piperazine ring were as potent as norfloxacin, ciprofloxacin and enoxacin. The oximes were almost as potent as the corresponding ketones against staphylococci but less active against Gram-negative bacteria. Some oximes were found to be more active than norfloxacin and enoxacin against Gram-positive organisms. In general, the O-benzyloxime derivatives had lower antibacterial activity than reference compounds. However, compounds having a 4-nitro group in the benzyl moiety of O-benzyloxime derivatives had antistaphylococcal activity greater than norfloxacin, ciprofloxacin and enoxacin. Generally, ciprofloxacin derivatives were more active than norfloxacin or enoxacin derivatives.
