202926-05-4Relevant articles and documents
Synthesis of 2-substituted nitrogen heterocycles using para-toluenesulfonyl iodide in a key step
Craig,Edwards,Muldoon
, p. 1441 - 1443 (2007/10/03)
N-Protected aminoalkenes undergo radical addition of tosyl iodide to give β-iodosulfones which can subsequently be induced to cyclise giving 2-substituted pyrrolidines and piperidines. Incorporation of an α-methylbenzyl group at nitrogen leads to a diastereoselective ring closure where the constituent diastereoisomers can be separated readily giving chiral, non-racemic heterocycles.