202982-40-9Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole
Lages, Adriana S.,Silva, Kelli C. M.,Miranda, Ana L. P.,Fraga, Carlos A. M.,Barreiro, Eliezer J.
, p. 183 - 188 (2007/10/03)
Four new aryl-sulfonamide derivatives (3a, 4a, 5a-b), having methylenedioxy group attached to phenyl ring, were prepared from natural safrole and evaluated as anti-inflammatory agents. The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay.
