202983-32-2

Usage

Uses

Used in Pharmaceutical Industry:
NF 279 is used as a potent and selective P2X1 antagonist for the development of therapeutic agents targeting the P2X1 receptor. Its high selectivity and potency make it a valuable compound for research and drug development in various conditions where the P2X1 receptor plays a significant role.
Used in Smooth Muscle Research:
In smooth muscle, NF 279 is used as a selective antagonist for studying the role of P2X receptors in muscle contraction and relaxation. Its IC50/KB value of approximately 1 μM makes it a useful tool for investigating the underlying mechanisms of smooth muscle function and potential therapeutic applications.
Used in Xenopus Oocytes Expression System:
NF 279 is used as a selective antagonist in the Xenopus oocytes pre-incubated with ATP to study the selectivity profile of P2X1, P2X2, P2X3, and P2X4 receptors. This application aids in understanding the receptor interactions and their roles in various physiological processes.
Used in Rat and Human Tissue Studies:
NF 279 is used to investigate the potency profile of rat P2X1, human P2X1, rat P2X2, rat P2X3, human P2X7, and human P2X4 receptors in rat and human tissues. This helps researchers to comprehend the differences in receptor activity and potential species-specific therapeutic approaches.

Biological Activity

A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.

Biochem/physiol Actions

Cell permeable: yes