20300-58-7Relevant academic research and scientific papers
Silver-Mediated Oxidative Decarboxylative Trifluoromethylthiolation of Coumarin-3-carboxylic Acids
Li, Minghao,Petersen, Jeffrey L.,Hoover, Jessica M.
supporting information, p. 638 - 641 (2017/02/10)
The introduction of trifluoromethylthio groups into organic compounds, in particular heterocycles, is important because of the prevalence of these structures in medicinally and agriculturally relevant molecules. Herein, the silver-mediated oxidative decarboxylative trifluoromethylthiolation of coumarin-3-carboxylic acids is reported. This methodology utilizes existing carboxylic acid functionalities for the direct conversion to CF3S groups and results in a broad scope of 3-trifluoromethylthiolated coumarins, including analogues of natural products, in moderate to excellent yields.
Lithium perchlorate and lithium bromide catalysed solvent free one pot rapid synthesis of 3-carboxycoumarins under microwave irradiation
Bandgar,Uppalla,Sadavarte
, p. 40 - 41 (2007/10/03)
Reaction of 2-hydroxy or 2-methoxy substituted benzaldehydes or acetophenones with Meldrum's acid in the presence of a catalytic amount of LiCIO4 or LiBr without solvent under microwave irradiation afforded 3-carboxycoumarins in excellent yields.
